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Acute tubular necrosis (ATN)

• Damage to epithelial cells in kidney tubules.
• Leads to oliguria that is unresponsive to fluids, which becomes polyuria in the recovery phase.
• Muddy-brown casts on urinalysis.
• Causes:-
- Severe kidney ischemia
- Contrast agent
- Medications (aminoglycosides, amphotericin)
- Hemo-/myoglobinuria
- Uric acid



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Acute tubular necrosis (ATN)

• Damage to epithelial cells in kidney tubules.
• Leads to oliguria that is unresponsive to fluids, which becomes polyuria in the recovery phase.
• Muddy-brown casts on urinalysis.
• Causes:-
- Severe kidney ischemia
- Contrast agent
- Medications (aminoglycosides, amphotericin)
- Hemo-/myoglobinuria
- Uric acid

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